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desvenlafaxine will improve the amount or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Monitor. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) reduce the CYP2D6 substrate dose by as much as 50%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive times prompt